Related Experiment Video

Updated: Apr 22, 2026

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

5.2K

Role of Appropriate Therapy in Combating Mortality among the Ventilated Patients

M V Pravin Charles1, Joshy M Easow2, Noyal M Joseph1

  • 1Assistant Professor, Department of Microbiology, Mahatma Gandhi Medical College and Research Institute , Pondicherry, India .

Journal of Clinical and Diagnostic Research : JCDR
|October 11, 2014
PubMed
Abstract

Insights

Inappropriate antibiotic therapy for ventilator-associated pneumonia (VAP) significantly increases patient mortality. Timely and accurate diagnosis, alongside appropriate antibiotic selection, is crucial for improving outcomes in intensive care unit (ICU) patients.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pulmonology

Background:

  • Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection in intensive care units (ICUs).
  • Despite infection control measures, VAP diagnosis remains challenging, contributing to high mortality rates.
  • Current diagnostic approaches may not consistently identify VAP accurately, necessitating improved diagnostic tools.

Purpose of the Study:

  • To evaluate the antibiotic treatment patterns in ICU patients diagnosed with VAP.
  • To assess the appropriateness of VAP treatment in relation to the Clinical Pulmonary Infection Score (CPIS).
  • To compare clinical outcomes between patients receiving appropriate versus inappropriate VAP therapy.

Main Methods:

  • Retrospective analysis of VAP patients in an ICU setting.
  • Utilized the Clinical Pulmonary Infection Score (CPIS) for VAP diagnosis.
  • Assessed antibiotic therapy appropriateness based on causative organism susceptibility patterns.

Main Results:

  • 50% of VAP patients (9 out of 18) died, compared to 8.6% of non-VAP patients.
  • Inappropriate antibiotic therapy was associated with a significantly higher mortality rate (80%) compared to appropriate therapy (38.5%).
  • VAP patients with positive blood cultures had a 100% mortality rate.

Conclusions:

  • High mortality rates in VAP patients underscore the need for accurate diagnosis and timely, appropriate antibiotic administration.
  • The study highlights the critical impact of antibiotic choice on VAP patient survival.
  • Implementing effective diagnostic strategies and antibiotic stewardship can reduce VAP-related mortality in ventilated patients.
Keywords:
APACHE (acute physiology and chronic health evaluation) II scoresClinical pulmonary infection scoreEndotracheal aspirateVentilator associated pneumonia

More Related Videos

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation07:15

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

Published on: December 5, 2025

768
Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide04:16

Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide

Published on: January 30, 2026

1.1K

Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
725
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
4.1K
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
4.1K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
803
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
1.1K
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
911