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Updated: Apr 22, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Multisite left ventricular pacing in cardiac resynchronization therapy.

James H P Gamble1, Tim R Betts

  • 1Oxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.

Future Cardiology
|October 11, 2014
PubMed
Summary
This summary is machine-generated.

Novel quadripolar pacing leads offer potential solutions for cardiac resynchronization therapy nonresponders and lead implantation challenges. This technology may improve treatment effectiveness for heart failure patients with dyssynchrony.

Keywords:
cardiac resynchronization therapymultisite left ventricular pacingmultisite pacingquadripolar pacing leads

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Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Cardiac resynchronization therapy (CRT) effectively treats heart failure with left bundle branch block dyssynchrony.
  • A significant portion of patients (around 33%) are nonresponders to CRT, and 5% experience lead implantation failure.

Purpose of the Study:

  • To review novel quadripolar pacing lead technology and its applications.
  • To discuss multisite pacing techniques using quadripolar leads for potential CRT improvement.

Main Methods:

  • Review of existing literature on quadripolar pacing leads.
  • Discussion of multisite pacing techniques, including pacing from two poles of a single quadripolar lead.

Main Results:

  • Quadripolar pacing leads and multisite pacing show potential to address CRT nonresponse and implantation issues.
  • Novel pacing strategies may enhance CRT outcomes in select heart failure patients.

Conclusions:

  • Quadripolar pacing technology presents a promising advancement in CRT.
  • Multisite pacing using quadripolar leads could improve CRT efficacy and patient selection.