Thrombosis: a major contributor to global disease burden

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Gary E Raskob1, Pantep Angchaisuksiri2, Alicia N Blanco3

  • 1College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

Seminars in Thrombosis and Hemostasis
|October 11, 2014
PubMed

Insights

Venous thromboembolism (VTE) significantly burdens global health, causing substantial disability-adjusted life-years lost, especially in hospitalized patients. Further data is needed to inform policy and prevention strategies for this widespread condition.

Area of Science:

  • Cardiovascular Medicine
  • Public Health
  • Epidemiology

Background:

  • Thrombosis, including venous thromboembolism (VTE), is a major cause of morbidity and mortality.
  • Ischemic heart disease and stroke account for a significant proportion of global deaths.
  • Data on the global disease burden of VTE was previously lacking.

Purpose of the Study:

  • To systematically review the global disease burden of VTE across different income countries.
  • To analyze VTE incidence rates and associated disability-adjusted life-years (DALYs).
  • To highlight the impact of VTE in both low- and high-income settings.

Main Methods:

  • Systematic literature review on the global disease burden of VTE.
  • Analysis of incidence data from various countries (Western Europe, North America, Australia, Argentina, China, Korea).
  • Assessment of VTE's contribution to DALYs compared to other hospital-acquired conditions.

Main Results:

  • Consistent VTE incidence rates (0.75-2.69 per 1,000) observed in developed nations, increasing with age.
  • VTE incidence is lower in Chinese and Korean populations but significant due to aging.
  • Hospital-associated VTE is a leading cause of DALYs lost in low- and middle-income countries, and second in high-income countries.

Conclusions:

  • Venous thromboembolism (VTE) represents a substantial global health burden across all income levels.
  • Hospital-associated VTE is a critical contributor to disability and premature death.
  • More comprehensive data on VTE burden is essential for effective health policy and resource allocation, including evaluating preventive measures.

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