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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

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Typical prenatal vitamin D supplement intake does not prevent decrease of plasma 25-hydroxyvitamin D at birth.

Marlies K Ozias1, Elizabeth H Kerling, Danielle N Christifano

  • 1a Department of Dietetics and Nutrition , University of Kansas Medical Center , Kansas City , Kansas.

Journal of the American College of Nutrition
|October 11, 2014
PubMed
Summary
This summary is machine-generated.

Maternal vitamin D levels significantly drop from mid-pregnancy to birth, with season and initial vitamin D status being key predictors. Standard prenatal vitamin D intake did not prevent this decline.

Keywords:
insufficiencypregnancyseasonsupplements and functional foodsvitamin D

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Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Maternal-Fetal Medicine

Background:

  • Maternal vitamin D deficiency is a growing concern during pregnancy.
  • Understanding predictors of vitamin D status change is crucial for maternal and infant health.

Purpose of the Study:

  • To identify predictors influencing changes in maternal vitamin D status from mid-pregnancy to birth.
  • To assess the impact of common factors like BMI, race, season, and supplementation on vitamin D levels.

Main Methods:

  • Longitudinal study tracking plasma 25-hydroxyvitamin D [25(OH)D] in 193 women at mid-pregnancy and post-birth.
  • Analysis of predictors including BMI, race, season, prenatal vitamin D intake, and docosahexaenoic acid (DHA) status.

Main Results:

  • A significant 61% drop in plasma 25(OH)D was observed from mid-pregnancy to birth.
  • Inadequate vitamin D status affected 49% of women at mid-pregnancy and 82% at birth.
  • Season of birth and mid-pregnancy 25(OH)D levels were significant predictors of change; BMI, race, DHA, and typical vitamin D intake were not.

Conclusions:

  • Standard prenatal vitamin D supplementation (334 IU/day) did not prevent significant declines in maternal 25(OH)D.
  • Clinicians should consider baseline vitamin D status and season of birth for pregnant women in the US due to high risk of deficiency.