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Updated: Apr 22, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Hierarchical supramolecular assembly of sterically demanding π-systems by conjugation with oligoprolines
Urszula Lewandowska1, Wojciech Zajaczkowski, Long Chen
1Laboratory of Organic Chemistry, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland).
Abstract:
Self-assembly from flexible worm-like threads via bundles of rigid fibers to nanosheets and nanotubes was achieved by covalent conjugation of perylene monoimide (PMI) chromophores with oligoprolines of increasing length. Whereas the chromophoric π-system and the peptidic building block do not self-aggregate, the covalent conjugates furnish well-ordered supramolecular structures with a common wall/fiber thickness. Their morphology is controlled by the number of repeat units and can be tuned by seemingly subtle structural modifications.
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