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Related Concept Videos

Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

301
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
301
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

166
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
166
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

127
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
127
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

285
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
285
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

160
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
160
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

380
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
380

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Updated: Apr 22, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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pH-responsive drug-delivery systems.

Ying-Jie Zhu1, Feng Chen

  • 1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (P. R. China), Fax: (+86) 21-52413122. y.j.zhu@mail.sic.ac.cn.

Chemistry, an Asian Journal
|October 11, 2014
PubMed
Summary
This summary is machine-generated.

pH-responsive drug delivery systems offer controlled release for biomedical applications. These smart systems target specific sites and times, improving therapeutic efficacy by utilizing the body

Keywords:
biomaterialsdrug carriersdrug deliverynanostructurespH-responsive

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Drug delivery often requires precise control matching physiological needs at targeted sites and release rates.
  • Varying pH levels across organs, tissues, and cellular compartments make pH a suitable stimulus for controlled release.
  • Conventional drug formulations have limitations that pH-responsive systems aim to overcome.

Purpose of the Study:

  • To review recent advancements in pH-responsive drug-delivery systems.
  • To discuss future perspectives in the field of pH-responsive drug delivery.
  • To highlight the potential of pH-responsive systems as smart drug-delivery solutions.

Main Methods:

  • Focus review of selected recent publications on pH-responsive drug-delivery systems.
  • Analysis of pH as a stimulus for controlled drug release in biomedical applications.

Main Results:

  • pH-responsive drug-delivery systems demonstrate potential for controlled drug release at specific sites and times.
  • These systems can achieve high therapeutic efficacy by overcoming conventional formulation shortcomings.
  • Recent progress shows promise in developing "smart" drug-delivery systems.

Conclusions:

  • pH-responsive drug delivery systems are a promising area of research for targeted and controlled therapeutic interventions.
  • The ability to respond to physiological pH variations offers significant advantages over traditional drug delivery methods.
  • Continued research and development are expected to further enhance the capabilities and applications of these smart systems.