[Modification of the atherogenic risk factor Lp(a) by supplementary fish oil administration in patients with moderate...

Influence of supplementary fish oil diet in patients with moderate physical training on the atherogenic risk factor Lp(a) 32 male patients (mean age 54.0 +/- 5.8 years) were treated with supplementary fish oil intake (8 ml/d) and daily moderate swim training (20 to 30 min) for four weeks. In 22 of the 32 patients lipoprotein Lp(a) was reduced significantly by 25.0%, apolipoprotein (apo) B by 11.4%, apo A I by 7.8%, triglycerides by 38.3%, and cholesterol by 12.3%. Possibly caused by too low dosed fish oil no drop of Lp(a) was seen in ten patients. Caloric reduced diet (5000 kJ/d) did not effect additional decrease of the Lp(a) level. A control group of 22 male patients (52.9 +/- 5.7 control group of 22 male patients (52.9 +/- 5.7 years) trained in the same way received a supplementary peanut oil diet (8 ml/d). There was no influence on Lp(a) by n-6 PUFA but cholesterol and triglycerides dropped significantly.