Related Experiment Video

Updated: Apr 22, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

1.2K

[Discrete plasmapheresis for coronary heart disease]

I N Solov'eva, Iu E Mikhaĭlov, M Iu Andrianova

    Terapevticheskii Arkhiv
    |October 14, 2014
    PubMed

    Insights

    Low-volume discrete plasmapheresis (PA) effectively improves abnormal homeostatic parameters in coronary heart disease (CHD) patients. This efficient therapeutic measure offers a pathogenetically sound approach to managing CHD, enhancing overall patient outcomes.

    Area of Science:

    • Cardiovascular Medicine
    • Therapeutic Apheresis
    • Internal Medicine

    Background:

    • Coronary heart disease (CHD) presents complex challenges in managing homeostatic dysregulation.
    • Current therapeutic strategies for CHD require continuous evaluation for enhanced efficacy.
    • Understanding the impact of apheresis on systemic homeostasis is crucial for treatment optimization.

    Purpose of the Study:

    • To establish the rationale for using discrete plasmapheresis (PA) as an efficient therapeutic intervention for CHD.
    • To evaluate the expediency and effectiveness of low-volume PA within a comprehensive CHD treatment package.

    Main Methods:

    • Conducted 120 cycles of low-volume therapeutic PA, totaling 585 sessions, in 91 patients diagnosed with CHD.
    • Monitored key parameters including blood lipid composition, hemocoagulation, rheology, and endotoxicosis.
    • Assessed the impact of plasma volume removal on homeostatic markers.

    Main Results:

    • Complete removal of circulating plasma volume per treatment cycle significantly improved abnormally elevated homeostatic parameters.
    • Key beneficial changes were observed in parameters related to lipid metabolism, coagulation, and systemic inflammation.
    • Crucially, levels of high-density lipoprotein cholesterol, antithrombin III, and albumin remained stable, indicating targeted and safe plasma component management.

    Conclusions:

    • Low-volume discrete PA is a pathogenetically justified and effective method for modulating homeostasis in patients with CHD.
    • This therapeutic approach offers a significant advancement in managing the complex pathophysiology of coronary heart disease.
    • The findings support the integration of low-volume PA into the therapeutic armamentarium for CHD.
    Abstract

    More Related Videos

    Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

    Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

    Published on: January 28, 2020

    4.9K
    Procedure for Decellularization of Porcine Heart by Retrograde Coronary Perfusion11:30

    Procedure for Decellularization of Porcine Heart by Retrograde Coronary Perfusion

    Published on: December 6, 2012

    23.4K

    Related Concept Videos

    Coronary Artery Disease V: Interprofessional Care01:27

    Coronary Artery Disease V: Interprofessional Care

    Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
    440
    Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

    Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

    Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
    371
    Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

    Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

    Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
    404
    Acute Coronary Syndrome IV: Interprofessional Care01:28

    Acute Coronary Syndrome IV: Interprofessional Care

    IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
    512
    Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

    Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

    Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
    1.1K
    Cardiomyopathy II: Dilated Cardiomyopathy01:30

    Cardiomyopathy II: Dilated Cardiomyopathy

    Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
    766