Related Experiment Video
Updated: Apr 22, 2026
04:04
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
Published on: July 5, 2024
1.3K
[Pathogenetic approaches to treating constipations]
Terapevticheskii Arkhiv
|October 14, 2014
Summary
Constipation has diverse causes and requires a pathogenetic treatment approach. This review details various laxative types, focusing on lactulose and its preparation, Duphalac, for effective constipation management.
Area of Science:
- Gastroenterology
- Pharmacology
Context:
- Constipation affects a significant portion of the population (15-25%) with varied underlying mechanisms.
- Understanding these mechanisms, including intestinal dyskinesia, slow transit, and defecatory discoordination, is crucial for effective treatment.
Purpose:
- To provide a comprehensive overview of constipation management strategies.
- To characterize different classes of laxatives and their efficacy, with a specific focus on lactulose.
Summary:
- The paper reviews various constipation types and their treatments, including prokinetics, spasmolytics like pinaverium bromide, biofeedback, and surgery.
- It categorizes laxatives into stimulant, osmotic, volume, and emollient types, alongside agents that stimulate defecation.
- Emphasis is placed on meta-analyses evaluating drug efficacy and the role of lactulose (Duphalac).
Impact:
- Highlights the importance of a pathogenetic approach for efficient constipation treatment.
- Offers insights into the comparative efficacy of different laxative groups based on meta-analyses.
- Underscores the therapeutic value of lactulose in managing constipation.
More Related Videos
Related Concept Videos
01:21Drugs for Treatment of Constipation-Predominant IBS
1.4K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.4K
01:17Drugs for Treatment of Diarrhea-Predominant IBS
990
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
990
01:17Chronic Bowel Disorders: Introduction
885
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
885
01:20Drugs Affecting GI Tract Motility: Other Laxatives
1.6K
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
1.6K
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
820
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
820
01:23Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
1.3K
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.3K