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Updated: Apr 22, 2026

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
Published on: April 19, 2024
Alveolar recruitment maneuver in mechanic ventilation pediatric intensive care unit children
Valéria Cabral Neves1, Adriana Koliski1, Dinarte José Giraldi2
1Unidade de Terapia Intensiva Pediátrica, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
Insights
Less aggressive ventilation, including alveolar recruitment maneuvers, improves survival in children with acute hypoxemic respiratory failure. This protective strategy reduces mortality and lung injury, but requires further pediatric investigation.
Area of Science:
- Pediatric Critical Care Medicine
- Respiratory Physiology
- Mechanical Ventilation
Background:
- Recent shifts in pediatric mechanical ventilation for acute hypoxemic respiratory failure emphasize less aggressive strategies.
- Evidence links inappropriate ventilation to delayed or worsened acute pulmonary injury.
- Protective ventilation combined with alveolar recruitment maneuvers (ARM) is emerging as a key intervention.
Purpose of the Study:
- To review the evidence for protective ventilatory strategies and ARM in pediatric acute lung injury.
- To assess the impact of ARM on oxygenation, alveolar collapse, and respiratory mechanics in children.
- To identify the benefits and limitations of ARM in pediatric patients with severe hypoxemia.
Main Methods:
- A literature review was conducted using MEDLINE, Pubmed, Cochrane library, SciELO, and Ovid databases (1998-2009).
- Included publications covered ARM in adults and children, encompassing review articles, experimental, and clinical trials.
- Keywords included: protective ventilatory strategy, alveolar recruitment maneuver, pediatrics, and mechanical ventilation.
Main Results:
- ARM shows beneficial effects on oxygenation and alveolar collapse in experimental models.
- Adult studies demonstrate improved pulmonary function and hypoxemia reversion with ARM.
- In children, ARM led to reduced inspired oxygen fraction, alveolar collapse, oxygen dependency, and bronchopulmonary dysplasia.
Conclusions:
- The combination of protective ventilation and ARM is associated with reduced morbidity, mortality, and ventilator-induced lung injury.
- ARM demonstrates positive effects on respiratory parameters in pediatric patients.
- Further research is warranted to establish definitive clinical evidence and application guidelines for ARM in children.
Abstract:
Recent changes were introduced in acute hypoxemic respiratory failure children ventilation methods. There are evidences that less aggressive ventilation strategies can improve severe pulmonary injury survival. Experimental trials evidenced a relationship between inappropriate ventilatory measures and delayed acute pulmonary injury improvement, or even worsening. From this, a protective ventilatory measure arises in combination with alveolar recruitment maneuver. This association is believed in clinical practice to determine importantly reduced morbidity and mortality as well as reduced mechanic ventilation-induced injuries. It is indicated for acute lung injury patients, generally from pneumonia or sepsis, with severe hypoxemia. Its main contraindications are homodynamic instability, pneumothorax and intracranial hypertension. Experimental trials showed beneficial maneuver effects on both oxygenation and alveolar collapse. Adult studies showed improved pulmonary function with hypoxemia reversion. In children, the maneuver lead to significant inspired oxygen fraction and alveolar collapse reductions, less oxygen dependency, improved pulmonary complacency, and reduced bronchopulmonary dysplasia. However, studies in children are limited. Additional investigation is warranted on this matter, and its clinical application evidence. A literature review was conducted based on textbooks and MEDLINE, Pubmed, Cochrane library, SciELO, and Ovid databases, from 1998 to 2009, both in Portuguese and English. Publications on alveolar recruitment maneuver both in adults and children, review articles, experimental and clinical trials were included using the key words: protective ventilatory strategy, alveolar recruitment maneuver, pediatrics and mechanic ventilation.
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