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Microfluidic conceived pH sensitive core-shell particles for dual drug delivery.

Ikram Ullah Khan1, Lukas Stolch2, Christophe A Serra3

  • 1Laboratory of Design and Application of Bioactive Molecules (CAMB), Faculty of Pharmacy, University of Strasbourg (UdS), Strasbourg, France; Charles Sadron Institute (ICS)-UPR 22CNRS, Precision Macromolecular Chemistry Group (CMP), Strasbourg, France; University of Strasbourg (UdS), European Engineering School of Chemistry, Polymers and Materials Science (ECPM), Strasbourg, France; Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.

International Journal of Pharmaceutics
|October 14, 2014
PubMed
Summary

We developed core-shell microparticles for dual drug delivery using microfluidics and UV polymerization. These particles enable controlled release of ketoprofen and ranitidine HCl, with pH-sensitive versions optimized for colon targeting.

Keywords:
CytotoxicityDual drug deliveryMicrofluidicsPoly(acrylamide-co-carboxy ethyl acrylate)pH-sensitive.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Sciences

Background:

  • Dual drug delivery systems are crucial for synergistic therapeutic effects and improved patient compliance.
  • Microfluidic techniques offer precise control over particle synthesis for advanced drug delivery applications.

Purpose of the Study:

  • To synthesize core-shell microparticles for co-delivery of ketoprofen and ranitidine HCl.
  • To investigate the influence of microfluidic parameters on particle characteristics and drug release.
  • To develop pH-sensitive microparticles for targeted colon delivery.

Main Methods:

  • Core-shell microparticles were fabricated using a two co-axial microfluidic device and UV-assisted free radical polymerization.
  • Particle size, shape, core diameter, and shell thickness were optimized by controlling flow rates (Qc, Qm, Qi).
  • Fourier-transform infrared spectroscopy (FTIR) confirmed polymerization, and MTT assays assessed cytotoxicity.

Main Results:

  • Monodispersed core-shell microparticles (100-151 μm) were produced with tunable core (58-115 μm) and shell dimensions.
  • Non-pH-sensitive particles exhibited simultaneous drug release, while pH-sensitive particles showed pH-dependent release profiles.
  • Optimized acrylamide concentration (30 wt%) and surfactant combinations prevented Janus structures.

Conclusions:

  • Microfluidics enables precise fabrication of core-shell microparticles for dual drug delivery.
  • Incorporation of pH-sensitive monomers allows for targeted drug release in the colon.
  • The developed system demonstrates potential for effective and targeted co-delivery of hydrophobic and hydrophilic drugs.