An effective method for improving outcomes in patients with a fertilization defect

Area of Science:

• Reproductive Medicine
• Embryology
• Infertility Treatment

Background:

• Recurrent implantation failure (RIF) poses a significant challenge in assisted reproductive technology (ART).
• Fertilization defects can contribute to RIF, necessitating advanced techniques.
• Intracytoplasmic morphologically selected sperm injection (IMSI) aims to improve sperm selection for better outcomes.

Purpose of the Study:

• To evaluate the efficacy of artificial oocyte activation (AOA) using a calcium ionophore in conjunction with IMSI.
• To assess the impact of this combined approach on pregnancy rates in patients with a history of RIF.

Main Methods:

• Patients with RIF underwent IMSI procedures.
• Artificial oocyte activation (AOA) was performed using a calcium ionophore.
• Embryo transfer was conducted following successful fertilization and embryo development.

Main Results:

• A total of 14 embryo transfers were performed.
• Five pregnancies were achieved, including four singleton and one twin pregnancy (35.7% success rate).
• The combined AOA and IMSI approach demonstrated positive pregnancy outcomes.

Conclusions:

• Artificial oocyte activation (AOA) combined with IMSI is a potentially effective strategy for patients experiencing RIF.
• This combination can address fertilization defects and improve success rates in challenging IVF cases.
• Consideration of AOA with IMSI may enhance treatment options for couples with repeated implantation failures.