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Identification, prevention and treatment of iron deficiency during the first 1000 days
Rachel M Burke1, Juan S Leon2, Parminder S Suchdev3
1Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd. NE, Atlanta, GA 30322, USA. rmburke@emory.edu.
Insights
Maternal and infant iron deficiency is a global health issue. This review covers iron status, consequences, and interventions during the critical first 1000 days of life.
Area of Science:
- Nutritional Science
- Maternal and Child Health
- Global Public Health
Background:
- Iron deficiency is a widespread global health problem affecting all life stages.
- Infants and mothers are particularly susceptible to iron deficiency and its adverse outcomes.
- Maternal iron deficiency during gestation increases offspring's risk of developing iron deficiency in infancy, potentially causing lifelong issues.
Purpose of the Study:
- To review iron status in mothers and infants during the first 1000 days (pregnancy to two years).
- To explore the role of iron, epidemiology, consequences, and identification of iron deficiency.
- To discuss interventions and identify research gaps in maternal and infant iron deficiency.
Main Methods:
- Literature review focusing on "first 1000 days" (pregnancy to 2 years).
- Analysis of iron's role, iron deficiency epidemiology, and consequences.
- Examination of identification methods and intervention strategies.
Main Results:
- Iron deficiency presents significant risks during pregnancy and early infancy.
- Consequences can be long-lasting, impacting lifelong health.
- Effective identification and intervention strategies are crucial.
Conclusions:
- Addressing iron deficiency in mothers and infants is critical for long-term health outcomes.
- Further research is needed to fill existing gaps in understanding and management.
- Comprehensive strategies are required to combat this global health challenge.
Abstract:
Iron deficiency is a global problem across the life course, but infants and their mothers are especially vulnerable to both the development and the consequences of iron deficiency. Maternal iron deficiency during pregnancy can predispose offspring to the development of iron deficiency during infancy, with potentially lifelong sequelae. This review explores iron status throughout these "first 1000 days" from pregnancy through two years of age, covering the role of iron and the epidemiology of iron deficiency, as well as its consequences, identification, interventions and remaining research gaps.
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