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Updated: Apr 22, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Systematic study of stress-inducible protein 1 (Stip1) in male reproductive system and its expression during stress
Yanwei Wang1, Shaohua Jin2, Ning Li1
1Central Laboratory, Yuhuangding Hospital, Yantai, Shandong Province, PR China.
Abstract:
Stress-inducible protein 1 (Stip1) is one of the well-studied co-chaperones, although limited researches have been conducted in testis and epididymis. Here we found that Stip1 was ubiquitously expressed in various human tissues, including the testis and epididymis. In human testis and epididymis, Stip1 was localized in the cytoplasm of diverse cell types. Stip1 showed a developmentally-regulated manner and it was up-regulated after heat shock in rat testis and epididymis. However, the expression of Stip1 was significantly down-regulated in the testis, with tremendous histomorphological changes under oxidative stress. This study will lay the foundation for revealing the mechanism of Stip1 in the male reproductive system.
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