Keratoderma palmoplantaris striata

Area of Science:

• Dermatology
• Genetics
• Pharmacology

Background:

• Keratoderma palmoplantaris striata is a rare inherited skin disorder.
• Understanding its familial incidence and treatment options is crucial for patient management.

Observation:

• A case of keratoderma palmoplantaris striata is detailed.
• A family tree revealed 36 affected relatives, indicating a significant familial incidence.
• This represents the largest reported familial incidence in the reviewed literature.

Findings:

• The patient exhibited striate palmoplantar keratoderma.
• Etretinate treatment resulted in an excellent response, effectively controlling skin lesions.
• Minimal side-effects were observed during the treatment period.

Implications:

• This case highlights the potential for high familial aggregation of keratoderma palmoplantaris striata.
• Etretinate is a viable and effective therapeutic option for managing this condition.
• Further research into the genetic basis and optimal treatment strategies for keratoderma palmoplantaris striata is warranted.