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Related Concept Videos

Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Dendriform pulmonary ossification.

Sebastián Fernández-Bussy1, Gonzalo Labarca2, Yumay Pires3

  • 1Division of Interventional Pulmonology sfernandezbussy@alemana.cl.

Respiratory Care
|October 16, 2014
PubMed
Summary
This summary is machine-generated.

Dendriform pulmonary ossification, a rare lung condition, can be diagnosed via bronchoscopy. This case highlights its potential role in diffuse lung disease diagnosis.

Keywords:
bronchoscopydiffuse lung diseaselung diseaseossification

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Area of Science:

  • Pulmonology
  • Pathology
  • Radiology

Background:

  • Dendriform pulmonary ossification (DPO) is an uncommon condition characterized by bone formation within the lungs.
  • Diagnosis is typically achieved through surgical resection or postmortem examination, limiting clinical understanding.

Observation:

  • A 43-year-old male presented with a year-long nonproductive cough.
  • Chest CT revealed bilateral lower lobe micronodules, but pulmonary function remained normal.
  • Flexible bronchoscopy with transbronchial biopsies demonstrated characteristic branching ossification.

Findings:

  • The case illustrates DPO in a living patient diagnosed via minimally invasive bronchoscopy.
  • Review of 42 reported cases indicates a strong predilection for autopsy diagnosis.
  • Pulmonary function tests were normal despite radiographic findings, suggesting DPO may not always impair lung function.

Implications:

  • DPO should be considered in the differential diagnosis of diffuse lung disease, even with normal pulmonary function.
  • Bronchoscopy with transbronchial biopsy is a valuable tool for diagnosing DPO in symptomatic patients.
  • This case expands the diagnostic possibilities for DPO beyond autopsy and surgery.