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Evaluation of peripheral arterial disease in prediabetes
Elham Faghihimani1, Ali Darakhshandeh1, Awat Feizi2
1Department of Internal Medicine, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
International Journal of Preventive Medicine
|October 16, 2014
Summary
Peripheral arterial disease (PAD) is common in asymptomatic patients with diabetes and prediabetes. Early detection and management of PAD, especially in hypertensive prediabetes patients, are crucial for preventing complications.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Public Health
Background:
- Increasing global prevalence of prediabetes poses significant atherosclerosis risk.
- Prediabetes and diabetes are associated with elevated cardiovascular disease risk.
- Peripheral arterial disease (PAD) is a critical manifestation of atherosclerosis.
Purpose of the Study:
- To determine the prevalence of PAD in prediabetes patients.
- To identify risk factors associated with PAD in prediabetes.
- To compare PAD prevalence across diabetes, prediabetes, and normal glucose tolerance groups.
Main Methods:
- Case-control study involving 135 adults in three groups: diabetes, prediabetes, and normal.
- Ankle-brachial index (ABI) measurement to assess PAD prevalence.
- Data collection included demographics, medical history, and risk factors like hypertension and HbA1C.
Main Results:
- PAD prevalence was higher in diabetes patients compared to the normal group (8.5% vs. 0.0%).
- No significant difference in PAD prevalence was found between prediabetes and diabetes/normal groups.
- Significant association between PAD and hypertension was observed in the prediabetes group (P < 0.01).
Conclusions:
- Peripheral arterial disease is prevalent in asymptomatic individuals with diabetes and prediabetes.
- Early detection of PAD is important for prediabetes and diabetes patients.
- Management of hypertension in prediabetes patients is critical for PAD prevention.
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