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Association Study of rs3184504 C>T Polymorphism in Patients With Coronary Artery Disease

Sarah Sadat Aghabozorg Afjeh1, Sayyed Mohammad Hossein Ghaderian1, Reza Mirfakhraie1

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

International Journal of Molecular and Cellular Medicine
|October 16, 2014
PubMed

Insights

This study found no direct link between the rs3184504 variant and coronary artery disease (CAD) risk in Iranians. However, the variant was associated with higher LDL cholesterol and diastolic blood pressure in this population.

Area of Science:

  • Genetics and Cardiovascular Health
  • Population-Specific Genetic Risk Factors

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality globally and in Iran.
  • Early diagnosis of coronary artery disease (CAD) is crucial for effective management and improved quality of life.
  • Limited research exists on genetic risk factors for CAD within the Iranian population.

Purpose of the Study:

  • To investigate the association between the rs3184504 C>T genetic variant and the risk of CAD in the Iranian population.
  • To explore potential links between the rs3184504 variant and key blood biochemical factors, including LDL cholesterol and diastolic blood pressure.

Main Methods:

  • A case-control study involving 200 participants (100 CAD cases, 100 controls) from the Iranian population.
  • DNA extraction from blood samples followed by genotyping of the rs3184504 variant using TaqMan Probe Real Time PCR.
  • Statistical analysis to evaluate the association between the variant and CAD risk, as well as with blood lipid and pressure levels.

Main Results:

  • No significant direct association was observed between the rs3184504 C>T variant and the risk of coronary artery disease in the studied Iranian cohort.
  • A statistically significant association was found between the rs3184504 variant and elevated levels of low-density lipoprotein (LDL) cholesterol.
  • The rs3184504 variant was also significantly associated with increased diastolic blood pressure in the Iranian population.

Conclusions:

  • The rs3184504 C>T variant does not appear to be a direct genetic risk factor for CAD in Iranians.
  • The variant's association with higher LDL and diastolic blood pressure suggests a potential role in cardiovascular risk pathways independent of direct CAD association in this population.
  • Further comprehensive molecular and association studies are warranted to elucidate the role of rs3184504 and other genetic factors in cardiovascular health among Iranians.

Keywords:
CADIranblood pressurepolymorphism

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