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Related Experiment Video

Updated: Apr 22, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

Unpredictable behavior of breast phyllodes tumors.

A Akcakaya¹, B Koc, F Erozgen

¹Department of Surgery, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey. ozgurkemik@hotmail.com.

European Review for Medical and Pharmacological Sciences

|October 16, 2014

Summary

Phyllodes tumors are rare breast tumors with potential for malignant transformation. This study evaluated 36 cases, highlighting the variable behavior and management of these fibroepithelial breast neoplasms.

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Area of Science:

Oncology
Pathology
Surgical Oncology

Background:

Phyllodes tumors are fibroepithelial neoplasms of the breast with a spectrum of clinical behavior, ranging from benign to malignant.
Accurate classification according to the World Health Organization (WHO) is crucial due to their variable malignant potential and risk of transformation.

Observation:

A retrospective analysis of 36 patients treated for phyllodes tumors was conducted.
The primary presentation in all cases was a breast lump, either new or recurrent.
Two detailed cases included a malignant transformation into sarcoma and a fatal metastatic phyllodes tumor in an adolescent.

Findings:

Phyllodes tumors can exhibit benign or malignant features, with malignant variants posing a fatal risk.
Even histologically benign phyllodes tumors may undergo malignant transformation over time.
The mean age of patients was 38 years, with all participants being female.

Implications:

Understanding the behavior of phyllodes tumors is critical for appropriate patient management and follow-up.
Early detection and accurate histopathological diagnosis are essential for effective treatment strategies.
Further research into the mechanisms of malignant transformation in phyllodes tumors is warranted.