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A synthesis of 6-deoxy-6-fluorosucrose suitable for PET applications
Xuefeng Gao1, Vikram Gaddam1, Michael Harmata1
1Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, United States.
Abstract:
A new route to 6-deoxy-6-fluorosucrose has been developed. The process proceeds in 8 linear steps in 25% overall yield from sucrose. The steps incorporating fluorine and subsequent deprotection are quite rapid, making the procedure useful in the context of 18F-labeling for PET applications.
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