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A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Group A streptococcal bacteremia without a source is associated with less severe disease in children
Stefanie Gauguet1, Asim A Ahmed, Jing Zhou
1From the *Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts; †Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts; ‡Clinical Research Center, Boston Children's Hospital, Boston, Massachusetts; §Department of Population Medicine, Harvard Medical School & Harvard Pilgrim Health Care Institute, Boston, Massachusetts; ¶Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; and ‖Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts.
Abstract:
We analyzed characteristics of 86 Group A streptococcal bacteremia cases at Boston Children's Hospital from 1992 to 2012. Twenty-three percent of children had severe disease, using intensive care unit admission (18), disability (7) or death (2) as indicators. Children with bacteremia without a source (30% of cases) were less likely to have severe disease than children with focal infections in adjusted models.
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