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Updated: Apr 22, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Primary intrathymic lymphangioma
Stefano Licci1, Francesco Puma2, Marta Sbaraglia3
1From Department of Pathology, "Santo Spirito" Hospital, Rome, Italy; stefano.licci@hotmail.it.
Objectives:
Lymphangiomas are relatively uncommon lesions of the lymphatic channels that can arise in virtually any part of the body provided by lymphatic vessels. The most common localization is the head/neck region, with only sporadic reports in other sites. The mediastinum is a rare location, with around 20 cases reported in the literature.
Methods:
We describe one case of mediastinal lymphangioma with a true intrathymic localization, which to our knowledge has never been described.
Results:
The gross features and microscopic findings are reported with a discussion of the clinicopathologic signatures of this pathologic entity.
Conclusions:
Intrathymic lymphangioma should always be taken into consideration in the differential diagnosis of cystic mediastinal lesions in children and adult patients.

