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Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Candida parapsilosis osteomyelitis.

Rekha Lopez1, Alistair Robert Hunter2, Orla Geoghegan3

  • 1Department of Microbiology, Imperial College NHS Healthcare Trust, London, UK.

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|October 17, 2014
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Summary
This summary is machine-generated.

A thumb injury led to a rare Candida parapsilosis infection. Prompt antifungal treatment and surgical debridement successfully resolved the infection, restoring thumb function.

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Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Mycology

Background:

  • A 51-year-old male sustained a severe right thumb injury, including partial amputation and a complex distal phalanx fracture.
  • Initial surgical management involved open reduction and internal fixation by the hand surgery team.

Observation:

  • Postoperatively, the patient developed a deep infection characterized by pus discharge two weeks after surgery.
  • Cultures from the surgical site and bone biopsy revealed *Candida parapsilosis* as the causative agent.
  • Empirical antibiotic treatment with ceftriaxone was initiated pending culture results.

Findings:

  • The patient underwent two radical debridement procedures to remove infected tissue and a K-wire.
  • Antifungal therapy was initiated with caspofungin, followed by a six-week course of oral fluconazole.
  • Histopathological analysis confirmed *Candida parapsilosis* in tissue and bone samples.

Implications:

  • This case highlights the potential for *Candida* species to cause deep-seated infections following orthopedic trauma and surgery.
  • Aggressive surgical debridement combined with targeted antifungal therapy is crucial for managing such infections.
  • Successful treatment led to complete resolution of infection and functional recovery of the thumb within three months.