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Updated: Apr 22, 2026

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
Published on: March 30, 2016
Time course of the rabbit's conditioned nictitating membrane movements during acquisition, extinction, and
E James Kehoe1, Elliot A Ludvig2, Richard S Sutton3
1School of Psychology, University of New South Wales, Sydney 2052, Australia j.kehoe@unsw.edu.au ejameskehoe@gmail.com.
Abstract:
The present experiment tested whether or not the time course of a conditioned eyeblink response, particularly its duration, would expand and contract, as the magnitude of the conditioned response (CR) changed massively during acquisition, extinction, and reacquisition. The CR duration remained largely constant throughout the experiment, while CR onset and peak time occurred slightly later during extinction. The results suggest that computational models can account for these results by using two layers of plasticity conforming to the sequence of synapses in the cerebellar pathways that mediate eyeblink conditioning.

