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Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Microbial Bioremediation of Plastics01:28

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Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
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Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
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Combinatorial approach to develop tailored biodegradable poly(xylitol dicarboxylate) polyesters.

Queeny Dasgupta1, Kaushik Chatterjee, Giridhar Madras

  • 1Bioengineering Program, ‡Department of Materials Engineering, and §Department of Chemical Engineering, Indian Institute of Science , Bangalore-560012, India.

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|October 17, 2014
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Summary
This summary is machine-generated.

Researchers developed tunable, biodegradable xylitol-based polyesters for biomedical uses. Varying synthesis parameters controlled degradation rates, mechanical strength, and release properties, yielding cytocompatible biomaterials.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Materials Engineering

Background:

  • Biodegradable polymers are crucial for biomedical applications, requiring precise control over degradation and mechanical properties.
  • Developing versatile synthesis strategies for tunable biomaterials remains a key challenge in materials science.

Purpose of the Study:

  • To create a flexible method for synthesizing xylitol-based cross-linked polyesters with adjustable characteristics.
  • To investigate how variations in diacid chain length, stoichiometry, and curing time influence polymer properties.
  • To assess the suitability of these polymers for biomedical applications through cytocompatibility testing.

Main Methods:

  • Synthesis of xylitol-based polyesters via melt condensation.
  • Systematic variation of diacid chain length, stoichiometric ratio, and post-polymerization curing time.
  • Characterization of physicochemical properties, including degradation rate, mechanical strength, and controlled release behavior.
  • Evaluation of polymer cytocompatibility.

Main Results:

  • Achieved a wide range of degradation rates (4-100% in 7 days) and mechanical strengths (0.5-15 MPa).
  • Demonstrated that increased diacid chain length reduced degradation rate.
  • Observed a linear decrease in degradation rate constant with increased polyester hydrophobicity.
  • Found that controlled release diffusion increased with chain length and curing time.
  • Confirmed cytocompatibility of the synthesized polymers.

Conclusions:

  • A combinatorial approach enables the preparation of biodegradable polymers with independently tunable properties.
  • Xylitol-based cross-linked polyesters offer a versatile platform for developing customized biomaterials.
  • These tunable, cytocompatible polymers are suitable for various biomedical applications.