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Oxidation-responsive Eu(2+/3+)-liposomal contrast agent for dual-mode magnetic resonance imaging
Levi A Ekanger1, Meser M Ali, Matthew J Allen
1Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA. mallen@chem.wayne.edu.
Chemical Communications (Cambridge, England)
|October 18, 2014
Abstract:
An oxidation-responsive contrast agent for magnetic resonance imaging was synthesized using Eu(2+) and liposomes. Positive contrast enhancement was observed with Eu(2+), and chemical exchange saturation transfer was observed before and after oxidation of Eu(2+). Orthogonal detection modes render the concentration of Eu inconsequential to molecular information provided through imaging.
