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Related Experiment Video

Updated: Apr 22, 2026

Use of the Scissor-Type Knife During the Peroral Endoscopy Myotomy Procedure for the Treatment of Achalasia
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Peroral endoscopic myotomy: establishing a new program.

Nikhil A Kumta1, Shivani Mehta1, Prashant Kedia1

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Clinical Endoscopy
|October 18, 2014
PubMed
Summary

Peroral endoscopic myotomy (POEM) offers a minimally invasive endoscopic treatment for achalasia, an esophageal motility disorder. This novel procedure demonstrates high success rates and low complication risks, making it a promising option for patients.

Keywords:
AchalasiaMyotomyNatural orifice endoscopic surgeryPeroral endoscopic myotomyTherapeutics

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Area of Science:

  • Gastroenterology and Endoscopy
  • Minimally Invasive Surgical Techniques

Background:

  • Achalasia is an esophageal motility disorder defined by impaired lower esophageal sphincter (LES) relaxation and esophageal aperistalsis.
  • Current achalasia treatments focus on reducing LES resting pressure.

Purpose of the Study:

  • To review clinical studies on the efficacy and safety of Peroral Endoscopic Myotomy (POEM) for achalasia treatment.
  • To propose a framework for establishing dedicated POEM programs and achieving procedural proficiency.

Main Methods:

  • POEM involves creating a submucosal tunnel in the esophagus, performing a myotomy, and closing the mucosal incision.
  • The procedure is derived from natural orifice transluminal endoscopic surgery (NOTES) and endoscopic submucosal dissection (ESD) techniques.

Main Results:

  • POEM has demonstrated a high treatment success rate of 90% in clinical studies.
  • The procedure is associated with low rates of complications.

Conclusions:

  • POEM is a novel, minimally invasive, and effective endoscopic treatment for achalasia.
  • Despite technical demands, POEM offers high success and low complication rates, supporting its increasing global adoption.