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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
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MACC1 overexpression and survival in solid tumors: a meta-analysis
Gang Wang1, Zhixuan Fu, Dechuan Li
1Department of Colorectal Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China.
Summary
Metastasis associated in colon cancer-1 (MACC1) overexpression is linked to poorer survival outcomes in solid tumors. This meta-analysis confirms MACC1 as a significant predictor of reduced overall, relapse-free, and disease-free survival.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Metastasis associated in colon cancer-1 (MACC1) is an identified oncogene.
- MACC1 overexpression is increasingly linked to tumor development and progression.
Purpose of the Study:
- To evaluate the association between MACC1 overexpression and survival in solid tumors through a meta-analysis.
Main Methods:
- A systematic literature search was conducted in Embase, PubMed, and Web of Science databases up to May 2014.
- Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a random-effect model.
- Included 20 studies covering overall survival (OS), relapse-free survival (RFS), and disease-free survival (DFS).
Main Results:
- High MACC1 expression strongly correlated with poor OS (HR 2.11, P < 0.001).
- Overexpressed MACC1 significantly predicted poor RFS (HR 2.22, P < 0.001).
- MACC1 overexpression unfavorably impacted DFS (HR 2.94, P < 0.001). Publication bias was not significant.
Conclusions:
- MACC1 overexpression is a significant indicator of poorer survival in patients with solid tumors.
- MACC1 serves as a potential prognostic biomarker for various solid malignancies.
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