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[The long-term use of obzidan in patients with hypertension]
Vrachebnoe Delo
|September 1, 1989
Insights
Anaprilin monotherapy reduced left ventricle mass in hypertensive patients. This treatment improved physical tolerance by decreasing myocardial wall thickness.
Area of Science:
- Cardiology
- Pharmacology
- Hypertension Research
Context:
- Hypertensive disease impacts cardiovascular health, often leading to left ventricle hypertrophy.
- Assessing the effects of beta-blocker monotherapy in managing hypertension-related cardiac changes.
Purpose:
- To investigate the impact of anaprilin (propranolol) monotherapy on left ventricle myocardial mass (MLVM) in hypertensive patients.
- To evaluate changes in cardiac structure and physical tolerance during prolonged anaprilin treatment.
Summary:
- A study involving 48 hypertensive patients monitored MLVM before and during anaprilin monotherapy.
- Most patients with initially elevated MLVM experienced a reduction starting from the third month.
- This reduction was attributed to decreased posterior wall and interventricular septum thickness, correlating with enhanced physical load tolerance.
Impact:
- Anaprilin monotherapy demonstrates potential in reversing hypertensive cardiac remodeling.
- Treatment may improve functional capacity and quality of life for patients with hypertensive heart disease.
Abstract:
The state of 48 patients with hypertensive disease was studied before and in the course of prolonged anaprilin monotherapy. Most patients with an initially increased mass of left ventricle myocardium (MLVM) showed beginning with the third month a reduction of this mass due to decrease in the thickness of the posterior wall and interventricular septum accompanied by an increased tolerance of the patients to physical load.