[Vasoactive polypeptides in rosacea]

Plasma kininogenesis components were studied in 110 patients with rosacea and in 3 groups of subjects at risk of developing this condition because of chronic gastrointestinal diseases, nervous system stress, or endocrine dysfunctions, conducive to rosacea. Changes in kininogenesis parameters similar to those detected in all rosacea patients were detected in all the 3 risk groups. Vasoactive polypeptide hyperproduction is a common component of rosacea pathogenesis. Vasoactive trend of the kinin action in kinin hyperproduction in rosacea induces vascular changes in the face and general vascular disorders, characteristic of this condition.