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Association of Inflammatory Cytokines with Traditional and Nontraditional Cardiovascular Risk Factors in Indians with

N Mahalle1, Mk Garg2, Mv Kulkarni3

  • 1Department of Pathology, Biochemistry Section, Deenanath Mangeshkar Hospital and Research Center, Erandwane, Pune, Maharashtra, India.

Annals of Medical and Health Sciences Research
|October 21, 2014
PubMed

Insights

Indian patients with coronary artery disease (CAD) exhibit elevated inflammatory markers like hsCRP, IL-6, and TNF-α. These markers correlate significantly with cardiovascular risk factors such as dyslipidemia, diabetes, and hypertension.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Inflammation plays a role in cardiovascular disease (CVD) etiology.
  • Limited data exists on inflammatory markers and CVD risk factors in Indian populations.

Purpose of the Study:

  • To assess the association between inflammatory markers and cardiovascular risk factors in Indian patients with coronary artery disease (CAD).

Main Methods:

  • Studied 300 CAD patients for serum highly sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α).
  • Evaluated anthropometry and traditional/nontraditional cardiovascular risk factors.
  • Utilized SPSS Version 20 for statistical analysis.

Main Results:

  • Elevated mean levels of hsCRP, IL-6, and TNF-α were observed.
  • Significant positive correlations found between inflammatory markers and dyslipidemia, diabetes mellitus, and hypertension.
  • Progressive increase in risk factors with higher inflammatory marker levels.

Conclusions:

  • Indian CAD patients present with significantly high inflammatory marker levels.
  • These elevated markers are strongly associated with prevalent cardiovascular risk factors.
Abstract

Keywords:
C-reactive proteinCoronary artery diseaseInflammatory markersInterleukin-6Tumor necrosis factor-α

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