Related Experiment Video
Updated: Aug 6, 2026
Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion
Published on: February 22, 2013
Cerebral blood flow following indomethacin administration
B P Lundell1, S E Sonesson, H Sundell
1Department of Pediatrics, S:t Göran's Children's Hospital, Karolinska Institute, Stockholm, Sweden.
Abstract:
Cerebral hemodynamics were studied in 7 term newborn lambs and 10 preterm infants with patent ductus arteriosus. Intracranial blood flow velocities were measured using a pulsed-wave Doppler velocimeter applied through the fontanel. Intravenous injection of indomethacin (0.2 mg.kg-1) reduced intracranial blood flow velocities in both lambs and infants. The CO2 reactivity, however, did not change in the lambs. Indomethacin administration is associated with reduced cerebral blood flow velocities but the pharmacological mechanism is unclear.
More Related Videos
04:32Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
Published on: October 23, 2020
06:24Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo
Published on: July 8, 2025