[Preparation and investigation of MRI-traceable Eudragit-E liquid embolic agent]

Area of Science:

• Biomaterials Science
• Interventional Radiology
• Medical Imaging

Background:

• Liquid embolic agents are crucial for minimally invasive procedures.
• The development of MRI-traceable agents enhances procedural guidance and confirmation.
• Eudragit-E offers a suitable matrix for embolic materials.

Purpose of the Study:

• To synthesize and characterize a novel MRI-traceable Eudragit-E liquid embolic agent (MR-E).
• To evaluate the MR traceability, deliverability, and embolization efficacy of MR-E.
• To establish optimal parameters for MR-E in preclinical settings.

Main Methods:

• Polyethylene glycol-modified superparamagnetic iron oxides (PEG-SPIO) synthesized via co-precipitation.
• MR-E prepared by homogeneous mixing of PEG-SPIO and Eudragit-E.
• In vitro phantom studies for MR traceability and PEG-SPIO concentration determination.
• In vivo study involving microcatheter delivery into rabbit renal arteries and MRI detection.

Main Results:

• A PEG-SPIO concentration of 2 g/L was found suitable.
• MR-E demonstrated excellent microcatheter deliverability and instant solidification upon release.
• Effective embolization of distal renal arteries was achieved with 0.2 mL of MR-E.
• MR-E was successfully detected by MRI in the embolized renal arteries.

Conclusions:

• MR-E exhibits promising characteristics as an MRI-traceable liquid embolic agent.
• The agent facilitates precise delivery and confirmation of embolization via MRI.
• Further investigation into MR-E for clinical applications is warranted.