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[Pregnancy jeopardized by pseudoxanthoma elasticum].

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Pregnancy in women with pseudoxanthoma elasticum (PXE) is rare. This case highlights placental calcification and twin intraventricular hemorrhage in a PXE patient, underscoring potential pregnancy complications.

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Area of Science:

  • Obstetrics and Gynecology
  • Medical Genetics
  • Radiology

Background:

  • Pseudoxanthoma elasticum (PXE) is a rare inherited disorder affecting elastic tissue.
  • PXE involves progressive calcification, with limited data on pregnancy outcomes.
  • Understanding PXE's impact on pregnancy is crucial for patient management.

Observation:

  • A 36-year-old woman with diagnosed PXE presented with a dichorionic diamniotic twin pregnancy.
  • Antenatal ultrasounds revealed a hyperechogenic placenta, indicative of calcification.
  • Post-partum placental histology confirmed significant calcification.

Findings:

  • The pregnancy resulted in premature delivery at 27 weeks via cesarean section due to maternal bleeding.
  • Both twins experienced intraventricular hemorrhage post-delivery.
  • Placental calcification in PXE may be associated with adverse pregnancy outcomes.

Implications:

  • This case emphasizes the need for vigilant monitoring during pregnancy for women with PXE.
  • Early detection and management of placental abnormalities in PXE pregnancies are vital.
  • Further research is needed to elucidate the risks and optimal care for pregnant PXE patients.