Related Experiment Video
Updated: Apr 21, 2026
An Isolated Retinal Preparation to Record Light Response from Genetically Labeled Retinal Ganglion Cells
Published on: January 26, 2011
[Progress in electrophysiological studies of retinal ganglion cells]
Xu-Jiao Zhou1, Zhong-Feng Wang, Ji-Hong Wu
1Research Center, Department of Ophthalmology at Eye & ENT Hospital, Fudan University, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China; Institutes of Brain Science, Fudan University, Shanghai 200032, China. lwnn2006@gmail.com; zfwang@fudan.edu.cn.
Abstract:
The knowledge about electrophysiological properties of retinal ganglion cells (RGCs), as well as modulation of these properties, is important not only for understanding the unique physiological functions of RGCs under normal conditions, but also for exploring the cellular mechanisms of retinal neurodegeneration diseases, such as glaucoma. In this paper, we reviewed the progress in electrophysiological studies of RGCs by using patch-clamp techniques, concerning the voltage-gated ion channels, the ligand-gated ion channels and the effects of neuromodulators on these channels.
