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Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
Published on: March 5, 2016
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Clofibrate increases long-chain fatty acid oxidation by neonatal pigs
Xiumei Bai1, Xi Lin2, Josephine Drayton1
1Laboratory of Developmental Nutrition, Department of Animal Science, North Carolina State University, Raleigh, NC; and.
The Journal of Nutrition
|October 22, 2014
Summary
Clofibrate supplementation may enhance long-chain fatty acid (LCFA) oxidation in neonatal pigs. This study investigated clofibrate
Area of Science:
- Neonatal physiology
- Nutritional biochemistry
- Metabolic regulation
Background:
- Neonatal development relies on efficient utilization of energy-dense lipid fuels.
- Optimizing milk fat utilization is crucial for newborn growth and survival.
Purpose of the Study:
- To evaluate the effect of clofibrate on in vivo and in vitro long-chain fatty acid (LCFA) oxidation in newborn pigs.
- To determine if clofibrate enhances milk fat utilization efficiency.
Main Methods:
- Newborn pigs were gavaged with clofibrate or vehicle for 4 days.
- In vivo LCFA oxidation was measured using radiolabeled triglycerides ([1-(14)C]TGs) in respiration chambers.
- Hepatic in vitro LCFA oxidation was assessed using radiolabeled oleic and erucic acids.
Main Results:
- Clofibrate tended to increase in vivo 24-h TG oxidation.
- Hepatic in vitro LCFA oxidation significantly increased by 61% with clofibrate.
- Clofibrate elevated mRNA for peroxisome proliferator-activated receptor α and its target genes.
Conclusions:
- Clofibrate shows potential to improve in vivo LCFA oxidative utilization in neonatal pigs.
- The drug appears to enhance hepatic fatty acid metabolism, particularly in mitochondria and peroxisomes.
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