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Updated: Apr 21, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
MicroRNAs in lung cancer.
Pooja Joshi1, Justin Middleton1, Young-Jun Jeon1
1Pooja Joshi, Justin Middleton, Young-Jun Jeon, Michela Garofalo, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, The Ohio State University, Columbus, OH 43210, United States.
MicroRNAs regulate genes involved in lung cancer development and therapy. Dysregulated microRNAs show potential as diagnostic biomarkers and therapeutic targets for improving lung cancer survival rates.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
- Dysregulated miRNA expression is implicated in various cancers, including lung cancer.
- Lung cancer has a low survival rate, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review the role of dysregulated microRNAs in lung tumorigenesis.
- To discuss the involvement of microRNAs in therapeutic resistance and as biomarkers.
- To explore the progress and challenges in miRNA-based lung cancer therapy.
Main Methods:
- Literature review of studies on microRNAs in lung cancer.
- Analysis of miRNA roles in lung tumorigenesis, epithelial-mesenchymal transition, and therapy response.
- Examination of current and future applications of miRNAs in lung cancer diagnosis and treatment.
Main Results:
- MicroRNAs are key regulators of cancer-related genes, impacting lung cancer development.
- Altered miRNA expression is linked to lung cancer progression and therapeutic resistance.
- MicroRNAs show promise as diagnostic and prognostic biomarkers.
Conclusions:
- Dysregulated microRNAs play a critical role in lung cancer initiation and progression.
- MicroRNAs represent a promising avenue for novel lung cancer diagnostics and therapeutics.
- Further research is needed to overcome challenges in miRNA-based lung cancer treatment.
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