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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
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Hemorrhagic transformation after cerebral infarction: current concepts and challenges
Jie Zhang1, Yi Yang1, Huijie Sun1
11 Neuroscience Center, Department of Neurology, 2 Cadre Ward, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
Annals of Translational Medicine
|October 22, 2014
Summary
Hemorrhagic transformation (HT) is a common stroke complication, particularly after thrombolytic therapy. Understanding HT
Area of Science:
- Neurology
- Vascular Medicine
- Stroke Research
Background:
- Hemorrhagic transformation (HT) frequently complicates acute ischemic stroke.
- The risk of HT restricts the use of tissue plasminogen activator (tPA) in stroke treatment.
Purpose of the Study:
- To review the incidence, classification, and predictors of HT.
- To explore the mechanisms, clinical outcomes, and current therapeutic strategies for HT.
- To highlight existing challenges in managing HT after ischemic stroke.
Main Methods:
- Literature review of studies on hemorrhagic transformation in acute ischemic stroke.
- Analysis of data regarding HT rate, classification, predictors, and clinical outcomes.
- Examination of current therapeutic approaches and treatment challenges.
Main Results:
- Hemorrhagic transformation is a significant complication of acute ischemic stroke.
- The risk of HT influences the application of thrombolytic therapy, such as tPA.
- Existing treatments for HT face several challenges, necessitating further research.
Conclusions:
- Further research is needed to address the challenges in managing hemorrhagic transformation.
- Optimizing treatment strategies for HT is crucial for improving outcomes in acute ischemic stroke patients.
- A comprehensive understanding of HT is essential for advancing stroke care.
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