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Selective neurotoxicity of clioquinol on the function of the posterior column nuclei
1Department of Neurology, University of Tsukuba, Japan.
Neuroscience Letters
|December 15, 1989
Abstract:
In the gracile nucleus of clioquinol-treated rats, the presynaptic inhibition was remarkably diminished, and the excitatory synaptic transmission was less intensely inhibited by a conditioning sural nerve volley. These changes may be the pathophysiology responsible for paresthesia and/or dysesthesia in patients with subacute optico-myelo-neuropathy (SMON).