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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Enzymatic aerobic ring rearrangement of optically active furylcarbinols
Daniel Thiel1, Diana Doknić1, Jan Deska1
1Department für Chemie, Universität zu Köln, Greinstrasse 4, 50939 Cologne, Germany.
Abstract:
Biogenic furans are currently discussed as highly attractive alternative feedstock in a post-fossil society; thus, also the creation of sustainable furan valorization pathways appears of great importance. Here an artificial Achmatowicz monooxygenase activity for the aerobic ring expansion of furans is achieved by the combination of commercial glucose oxidase as oxygen-activating biocatalyst and wild-type chloroperoxidase as oxygen-transfer mediator, providing a biological ready-to-use solution for this truly synthetic furan rearrangement. In concert with enzymatic transformations for the enantioselective preparation of optically active furylcarbinols, purely biocatalytic reaction cascades for the stereocontrolled construction of complex pyranones are obtained, exhibiting high functional group tolerance even to oxidation-sensitive moieties.
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The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

