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Updated: Apr 21, 2026
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Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
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Management of antidepressant-induced sexual dysfunction
Nicholas A Keks1, Judy Hope2, Christine Culhane3
1Monash University and; Centre of Mental Health Education and Research at Delmont Private Hospital, Glen Iris, VIC, Australia nicholas.keks@monash.edu.
Summary
Antidepressant-induced sexual dysfunction is common and often unreported, impacting treatment adherence. Some antidepressants pose higher risks, necessitating careful patient monitoring and management strategies.
Area of Science:
- Pharmacology
- Psychiatry
- Sexual Medicine
Background:
- Antidepressant-induced sexual dysfunction (AISD) is a frequent adverse effect of pharmacotherapy for depression.
- Patients frequently do not report AISD, leading to treatment non-adherence and potential relapse.
- Understanding AISD's prevalence, causes, and management is crucial for clinical practice.
Purpose of the Study:
- To review the extent, causation, and evidence-based management of antidepressant-induced sexual dysfunction.
- To inform clinical practice regarding the identification and treatment of AISD.
Main Methods:
- Literature review of studies on antidepressant-induced sexual dysfunction.
- Analysis of evidence regarding risk factors, patient demographics, and treatment outcomes.
Main Results:
- Antidepressants can be categorized by risk: high-risk (SSRIs, SNRIs, TCAs, MAOIs) and low-risk (agomelatine, bupropion, moclobemide, reboxetine).
- AISD is dose-dependent but influenced by patient vulnerability and differs between sexes.
- Proactive inquiry about sexual dysfunction is vital as self-reporting is low.
Conclusions:
- Consider low-risk antidepressants for initial treatment to minimize AISD.
- Management strategies include waiting for tolerance, switching to lower-risk agents, or using combinations.
- Adjunctive sildenafil may be beneficial for both men and women experiencing AISD.
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