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[Digital ulcers in systemic scleroderma].

D Belz1, N Hunzelmann, P Moinzadeh

  • 1Klinik und Poliklinik für Dermatologie und Venerologie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland, doreen.belz@uk-koeln.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|October 23, 2014
PubMed
Summary
This summary is machine-generated.

Digital ulcers (DU), a common scleroderma symptom, necessitate medical care. Treatments like Iloprost and Bosentan show promise in healing and preventing new DU occurrences.

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Area of Science:

  • Rheumatology and Dermatology
  • Vascular Medicine

Background:

  • Digital ulcers (DU) are a significant manifestation of systemic scleroderma, affecting approximately 60% of patients.
  • DU complications include infection, gangrene, and amputation, requiring diligent medical and nursing wound management.
  • A standardized definition for DU is currently lacking.

Purpose of the Study:

  • To review current therapeutic approaches for digital ulcers in systemic scleroderma.
  • To highlight established and emerging treatments for DU management.

Main Methods:

  • Literature review of DU treatment strategies.
  • Analysis of European League Against Rheumatism (EULAR) guidelines from 2009.
  • Summary of findings on Iloprost, Bosentan, and PDE-5 inhibitors.

Main Results:

  • Iloprost has demonstrated efficacy in improving the healing of active digital ulcers.
  • Bosentan has been shown to significantly decrease the incidence of new digital ulcers.
  • Preliminary studies suggest potential benefits of PDE-5 inhibitors in DU treatment.

Conclusions:

  • Current treatments offer varying degrees of success in managing digital ulcers.
  • Further research into novel therapeutic strategies for digital ulcers is warranted.