Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

15.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.3K
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

678
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
678
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

746
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
746
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

948
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
948
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiovascular risks and hazards associated with deep space exploration.

Communications medicine·2026
Same author

Effects of voluntary exercise, diet, and selenium on hypothalamic adult neurogenesis.

Stem cell reports·2026
Same author

SVM-Based Optical Detection of Retinal Ganglion Cell Apoptosis.

Photonics·2026
Same author

Feasibility of using head up patient position in maintaining low central venous pressure and restricting the need for pharmacological agents during major hepatectomy.

Annals of hepato-biliary-pancreatic surgery·2026
Same author

Simulating Cancer Recurrence Patterns From Post-Treatment Viable Tumor Burden Distributions.

JCO clinical cancer informatics·2026
Same author

The role of diffusion-weighted MRI in biological image-guided radiation therapy: a roadmap.

Physics in medicine and biology·2026

Related Experiment Video

Updated: Apr 21, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.8K

Cardiovascular risks associated with low dose ionizing particle radiation.

Xinhua Yan1, Sharath P Sasi2, Hannah Gee2

  • 1Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America; Tufts University School of Medicine, Boston, Massachusetts, United States of America.

Plos One
|October 23, 2014
PubMed
Summary
This summary is machine-generated.

Low-dose proton irradiation initially improved cardiac function post-ischemia, while iron ion irradiation worsened outcomes. Understanding these charged particle radiation effects is crucial for astronaut safety and radiotherapy patients.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K
An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes
08:23

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes

Published on: December 25, 2021

4.0K

Related Experiment Videos

Last Updated: Apr 21, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.8K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K
An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes
08:23

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes

Published on: December 25, 2021

4.0K

Area of Science:

  • Cardiovascular Biology
  • Radiation Biology
  • Space Medicine

Background:

  • Ionizing radiation exposure, including charged particles, poses long-term cardiovascular risks.
  • Proton and carbon ion radiotherapy use is increasing, necessitating understanding of their cardiac effects.
  • Space exploration missions expose astronauts to significant radiation doses, raising concerns for cardiovascular health.

Purpose of the Study:

  • To investigate the long-term cardiovascular effects of low-dose proton and iron ion irradiation in mice.
  • To assess the impact of prior irradiation on cardiac function and remodeling following acute myocardial infarction (AMI).

Main Methods:

  • Whole-body irradiation of mice with protons (0.5 Gy, 1 GeV) and iron ions (0.15 Gy, 1 GeV/nucleon).
  • Assessment of cardiac function and remodeling at various time points up to 10 months post-irradiation.
  • Induction of acute myocardial ischemia (AMI) in a subset of irradiated mice to evaluate recovery.

Main Results:

  • Proton irradiation initially improved cardiac function but declined by 10 months; it enhanced recovery and remodeling post-AMI.
  • (56)Fe ion irradiation significantly reduced cardiac function at 1-3 months, with recovery by 10 months; it led to poorer outcomes and adverse remodeling post-AMI.
  • Proton irradiation increased pro-survival gene expression, while iron ion irradiation decreased angiogenesis and pro-survival factors post-AMI.

Conclusions:

  • Low-dose proton irradiation has complex, time-dependent effects on cardiac function and can be protective post-AMI.
  • Iron ion irradiation induces significant cardiac dysfunction and adverse remodeling, particularly following AMI, linked to reduced angiogenesis.
  • Understanding differential charged particle radiation effects is vital for mitigating cardiovascular risks in radiotherapy patients and astronauts.