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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Apr 21, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Primary penile melanoma.

R Andrei, Mirela Cioplea, V Mageriu

    Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne
    |October 24, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Primary penile melanoma, a rare cancer, often affects the glans in older men and has a poor prognosis due to late diagnosis. This case highlights a 77-year-old male successfully treated for glanular melanoma.

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    Area of Science:

    • Oncology
    • Dermatology
    • Urology

    Background:

    • Primary penile melanomas are rare, accounting for less than 1% of penile cancers, with over half occurring on the glans.
    • These tumors typically affect older individuals and often present with a poor prognosis due to delayed diagnosis.

    Observation:

    • A case report details a 77-year-old male with a pigmented, ulcerated nodular melanoma of the glans.
    • The lesion measured 4.5 mm in thickness with a mitotic index of 8 mitoses/mm² and vascular emboli.
    • No lymph node involvement or distant metastases were detected at the time of diagnosis.

    Findings:

    • The patient remained disease-free six months post-diagnosis and treatment.
    • Differential diagnosis can be challenging, with potential confusion with squamous cell carcinoma, nevi, pyogenic granuloma, or Kaposi sarcoma.
    • Histopathological examination is crucial, especially for distinguishing primary penile melanoma from metastatic melanoma.

    Implications:

    • Early detection and diagnosis are critical for improving outcomes in primary penile melanoma.
    • Treatment strategies are not standardized but frequently involve wide surgical excision, penectomy, and sentinel lymph node biopsy.
    • Adjuvant therapies like chemotherapy or interferon may be considered for advanced or metastatic disease.