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Microarray and next-generation sequencing to analyse gastric cancer
Yuan Dang1, Ying-Chao Wang, Qiao-Jia Huang
1Department of Experimental Medicine, Fuzhou General Hospital (Dongfang Hospital), Fuzhou, China
Abstract:
Gastric cancer is the second after lung cause of cancer-related mortality in the world. Early detection and treatment can lead to a long survival time. Recently microarrays and next generation sequencing (NGS) have become very useful tools of comprehensive research into gastric cancer, facilitating the identification of treatment targets and personalized treatments. However, there are numerous challenges from cancer target discovery to practical clinical benefits. Although there are many biomarkers and target agents, only a minority of patients are tested and treated accordingly. Microarray technology with maturity was established more than 10 years ago, and has been widely used in the study of functional genomics, systems biology, and genomes in medicine. Second generation sequencing technology is more recent, but development is very fast, and it has been applied to the genome, including sequencing and epigenetics and many aspects of functional genomics. Here we review insights gained from these studies regarding the technology of microarray and NGS, how to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets, and how to analyse candidate genes. We also discuss the challenges and future directions of such efforts.
Insights
Gastric cancer research uses microarray and next-generation sequencing (NGS) to find new treatments. These technologies help identify molecular targets for personalized gastric cancer therapies, though challenges remain in clinical application.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Gastric cancer is a leading cause of cancer mortality worldwide.
- Early detection and targeted treatments are crucial for improving patient survival.
- Advanced genomic technologies are transforming gastric cancer research.
Purpose of the Study:
- To review insights from microarray and next-generation sequencing (NGS) in gastric cancer research.
- To discuss the elucidation of the molecular basis of gastric cancer.
- To identify potential therapeutic targets and analyze candidate genes.
Main Methods:
- Review of studies utilizing microarray technology for functional genomics and systems biology.
- Analysis of applications of next-generation sequencing (NGS) in genome, epigenetics, and functional genomics.
- Examination of methods for analyzing candidate genes in gastric cancer.
Main Results:
- Microarray and NGS technologies provide comprehensive insights into gastric cancer molecular mechanisms.
- These technologies facilitate the identification of potential therapeutic targets and biomarkers.
- Challenges exist in translating discoveries into clinical benefits for gastric cancer patients.
Conclusions:
- Microarray and NGS are powerful tools for advancing gastric cancer research and personalized medicine.
- Further efforts are needed to overcome challenges in target discovery and clinical implementation.
- Future directions involve refining these technologies for broader clinical application in gastric cancer treatment.
