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Mycobacterial skin and soft tissue infection
Shu-Hua Wang1, Preeti Pancholi
1Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University Wexner Medical Center, N-1120 Doan Hall, Columbus, OH, 43210, USA, Shu-Hua.Wang@osumc.edu.
Current Infectious Disease Reports
|October 24, 2014
Summary
Diagnosing mycobacterial skin infections like NTM, TB, and leprosy is challenging. Newer molecular diagnostics and proteomics offer improved identification of mycobacteria species, enhancing treatment outcomes.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Mycobacterial skin and soft tissue infections (SSTI) encompass nontuberculous mycobacterial (NTM) infections, tuberculosis (TB), and leprosy.
- Diagnosis is often difficult due to varied presentations, low culture yields, and nonspecific biopsy findings.
- Immunosuppressed individuals may exhibit atypical or disseminated disease, complicating management.
Purpose of the Study:
- To review updates in diagnostic tests for mycobacterial SSTI.
- To discuss clinical presentations and treatment strategies for NTM, TB, and leprosy.
- To highlight advancements in identifying clinically significant mycobacteria species.
Main Methods:
- Review of current literature on mycobacterial SSTI diagnostics and therapeutics.
- Focus on advancements in molecular diagnostics and proteomics (e.g., MALDI-TOF MS).
- Analysis of diagnostic challenges and treatment outcomes.
Main Results:
- Traditional methods like biopsy and culture have limitations.
- Newer molecular and proteomic techniques improve species identification speed and accuracy.
- Despite treatment, outcomes can be suboptimal, often due to side effects and drug interactions.
Conclusions:
- Enhanced diagnostic tools are crucial for timely and accurate identification of mycobacterial SSTI.
- Improved diagnostics can lead to more effective and personalized treatment strategies.
- Ongoing research is vital to overcome challenges in managing these infections.
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