Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
Bone Disorders01:29

Bone Disorders

7.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.9K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

351
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
351
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

369
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
369
Mitochondria01:37

Mitochondria

13.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer.

Signal transduction and targeted therapy·2026
Same author

Retraction Note: Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells.

Experimental & molecular medicine·2026
Same author

Detection of atrial fibrillation via adhesive single-lead ECG vs. Holter monitoring in embolic stroke of undetermined source: the AVANT-GARDE trial.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

Effects of Mind-Muscle Connection on Muscle Activity During Machine-Based Shoulder Press in Untrained Individuals.

Journal of clinical medicine·2026
Same author

Ribonuclease DIS3 delays aging and senescence by generating tRNA halves.

Nature communications·2026
Same author

Cohesin and NuRD Antagonistically Drive Alternative Neuronal Fates via PLZF Transcription Factors.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Apr 21, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
06:18

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

5.7K

Effects of nutritional components on aging.

Dongyeop Lee1, Wooseon Hwang, Murat Artan

  • 1Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.

Aging Cell
|October 24, 2014
PubMed
Summary

Understanding nutrient roles in aging is key. This review explores how carbohydrates, proteins, lipids, vitamins, and minerals impact lifespan and healthspan, offering insights into longevity.

Keywords:
agingamino acidcarbohydratelipidmineralnutrientproteinvitamin

More Related Videos

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.2K

Related Experiment Videos

Last Updated: Apr 21, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
06:18

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

5.7K
Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.2K

Area of Science:

  • Nutritional science
  • Gerontology
  • Molecular biology

Background:

  • Nutrients are vital for physiological processes and survival.
  • Caloric restriction is known to delay aging across species.
  • The specific impact of individual nutrients on lifespan remains unclear.

Purpose of the Study:

  • To review recent research on the regulatory role of specific nutrients in aging.
  • To discuss how nutrient quantity and composition influence human longevity and healthspan.

Main Methods:

  • Literature review of recent studies on nutrient-specific aging.
  • Analysis of data linking nutrient intake to lifespan and health outcomes.

Main Results:

  • Emerging evidence suggests distinct roles for carbohydrates, proteins, lipids, vitamins, and minerals in aging regulation.
  • Specific dietary patterns and nutrient compositions show correlations with extended longevity and improved healthspan.

Conclusions:

  • Individual nutrients play significant roles in the aging process, beyond overall caloric intake.
  • Understanding these specific roles can inform strategies for promoting human longevity and healthspan.