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Tumor-infiltrating lymphocytes in breast cancer: A new predictor for responses to therapy
Yasmin Issa-Nummer1, Sibylle Loibl1, Gunter von Minckwitz1
1German Breast Group; Neu-Isenburg, Germany.
Oncoimmunology
|October 24, 2014
Abstract:
We have prospectively validated in an independent clinical cohort the finding that elevated amounts of tumor-infiltrating lymphocytes in breast carcinoma tissues predict the response of patients to neoadjuvant chemotherapy. These results suggest that a robust tumor infiltration by T and B cells is a promising biomarker to define patients who might benefit from neoadjuvant chemotherapy.

