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Updated: Apr 21, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma
Meriem Messaoudene1, Marie-Françoise Avril2, Anne Caignard1
1Institut Cochin, INSERM U1016; CNRS UMR 8104; Université Paris Descartes; Paris, France.
Abstract:
In metastatic melanoma patients, circulating natural killer (NK) cells display phenotypic and functional alterations that appear to correlate with the duration of stage IV disease. Moreover, specific NK cell subsets that exhibit robust tumoricidal functions upon activation by cytokines infiltrate the diseased lymph nodes of these patients. These data suggest that NK cells may be harnessed for the development of novel combinatorial immunotherapies against melanoma.
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