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Neuroblastoma accompanied by hyperaldosteronism.
Kaan Gulleroglu1, Umut Bayrakci1, Sibel Tulgar Kinik2
1Department of Pediatric Nephrology, Baskent University, Ankara, Turkey.
Journal of Renal Injury Prevention
|October 24, 2014
Summary
Neuroblastoma, a rare cause of secondary hyperaldosteronism, can present atypically in children. This case highlights the importance of considering unusual etiologies for hyperaldosteronism in pediatric patients.
Area of Science:
- Pediatric Endocrinology
- Pediatric Oncology
- Nephrology
Background:
- Secondary hyperaldosteronism is typically associated with renal tumors like juxtaglomerular cell tumors and Wilms' tumors.
- Neuroblastoma presenting with hyperaldosteronism is an uncommon clinical presentation.
Observation:
- A 15-month-old girl presented with severe hypokalemia, metabolic acidosis, hypertension, and gastrointestinal symptoms.
- Initial assessment suggested hyperaldosteronism due to elevated serum aldosterone and plasma renin activity.
- Radiological and histopathological findings confirmed neuroblastoma as the underlying cause.
Findings:
- The patient exhibited symptoms consistent with hyperaldosteronism, including hypertension and severe hypokalemia.
- Elevated serum aldosterone and plasma renin activity supported the diagnosis of hyperaldosteronism.
- Histopathological examination confirmed neuroblastoma, establishing it as the etiology.
Implications:
- This case underscores the importance of considering rare causes of hyperaldosteronism in pediatric patients.
- Early diagnosis and surgical management of neuroblastoma are crucial for resolving hyperaldosteronism.
- Highlights the atypical presentation of neuroblastoma in the context of secondary hyperaldosteronism.
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